Aghdasi-Bornaun H, Kutluk G, Keskindemirci G, Öztarhan K, Dedeoğlu R, Yılmaz N, Tosun Ö.Turk J Pediatr. 2018;60(4):407-414. doi: 10.24953/turkjped.2018.04.008.
Abstract for Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission
Heart Rate Variability (HRV) is one of the reliable and noninvasive parameters to evaluate autonomic control of the cardiovascular system in patients. The aim of our study was to assess autonomic function in pediatric patients with inflammatory bowel disease (IBD) in remission using Power Spectral Analysis of HRV. Autonomic cardiovascular function was evaluated by time and frequency-domain indexes of spontaneous heart rate in 36 IBD children patients in remission phase and 36 sex and age matched healthy controls. Twenty children with Ulcerative Colitis (UC) and 16 patients with Crohn`s disease (CD) were diagnosed according to their history, physical and laboratory examination, endoscopic, histopathological and radiological findings of upper and lower gastrointestinal system. Significant decrease was observed at HRV parameters in IBD patients when compared with control group. These differences was found in some of time domain parameters (NNmean, SDNNtotal, SDNNday) and frequency domain parameters (TP, LF,VLF) (p < 0.05). Also, there was a significant higher minimum heart rate ratio (p < 0.04) in patients in comparison to the control group. In the IBD group, there was a relative tendency for parasympathetic suppression and sympathetic predominance which reflects an autonomic dysfunction. This imbalance has a circadian rhythm and it is more obvious during the day. These observations may suggest a previously unrecognized role of chronic inflammation for autonomic modulation in IBD.
Keywords: heart rate variability; inflammatory bowel disease; pediatrics.
Uzman Dr. Nuh YILMAZ
Specialist Dr. Nuh Yılmaz, after his medical education at Ege University Faculty of Medicine, he completed his residency in Pediatrics at İzmir Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital. He completed his subspecialty training in Pediatric Cardiology at Dokuz Eylül University Faculty of Medicine. After working as a Pediatric Cardiology Specialist at Liv Hospital Vadi Istanbul Hospital and Istanbul Medical Park Bahçeşehir Hospital, he started accepting patients at İskenderun Gelişim Hospital.