Correlations with B-type natriuretic peptide and tissue Doppler findings
Kır M, Cetin B, Demir K, Yılmaz N, Kızılca O, Demircan T, Unal N, Bober E, Saylam GS.Pediatr Diabetes. 2016 Feb;17(1):21-7. doi: 10.1111/pedi.12234. Epub 2014 Nov 11.
Abstract for Can ambulatory blood pressure monitoring detect early diastolic dysfunction in children with type 1 diabetes mellitus
Aim: To evaluate the relationship between 24-h blood pressure (BP) measurements and diastolic heart function evaluated by Doppler tissue imaging and B-type natriuretic peptide (BNP) levels in children with type 1 diabetes mellitus (DM).
Patients and methods: A total of 32 diabetic and 18 healthy children were enrolled. Spectral Doppler analysis and tissue Doppler measurements were performed by conventional echocardiography. The 24-h ambulatory BP and serum BNP levels were measured.
Results: Analysis of ambulatory blood pressure monitoring (ABPM) recordings showed that median daytime diastolic BP load were significantly higher in diabetic patients compared to controls [12.35 (4.23-27.23) vs. 2.5 (0-8.7), p = 0.007]. Patients with elevated daytime systolic and diastolic BP loads had significantly higher BNP values compared to patients with normal BP load (31.4 ± 24.36 vs. 11.84 ± 11.25 pg/mL, p = 0.03 and 23.21 ± 15.12 vs. 12.12 ± 14.65 pg/mL, p = 0.03, respectively). Isovolemic contraction time (47.43 ± 7.84 vs. 42.27 ± 7.47, p = 0.045), isovolemic relaxation time (68.84 ± 10.43 vs. 58.77 ± 10.02, p = 0.02), and myocardial performance index (0.45 ± 0.10 vs. 0.37 ± 0.09, p = 0.02) as determined by tissue Doppler echocardiography were significantly high in diabetic patients compared to that of control cases. Ratio of mitral peak early diastolic flow velocity (E) to peak early diastolic myocardial velocities by tissue Doppler echocardiography (E’) was also higher in patients with elevated daytime systolic BP load (E/E’, 6.71 ± 1.97 vs. 4.91 ± 1.02, p = 0.04).
Conclusion: Elevated BP loads detected by 24-h ambulatory BP measurements in children with type 1 diabetes are associated with increased BNP levels and abnormal tissue Doppler echocardiography indices, indicating early stage cardiac dysfunction.
Keywords: ambulatory blood pressure; diabetic children; diastolic function.
Uzman Dr. Nuh YILMAZ
Specialist Dr. Nuh Yılmaz, after his medical education at Ege University Faculty of Medicine, he completed his residency in Pediatrics at İzmir Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital. He completed his subspecialty training in Pediatric Cardiology at Dokuz Eylül University Faculty of Medicine. After working as a Pediatric Cardiology Specialist at Liv Hospital Vadi Istanbul Hospital and Istanbul Medical Park Bahçeşehir Hospital, he started accepting patients at İskenderun Gelişim Hospital.